About InVivoMAb anti-mouse Ly6G/Ly6C

The NIMP-R14 monoclonal antibody is specific for murine neutrophils. The antibody is reported to react strongly with mouse Ly6G and Ly6C previously referred to as GR-1. Ly6G is a 21-25 kDa member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Ly6G is expressed differentially during development by cells in the myeloid lineage including monocytes, macrophages, granulocytes, and neutrophils. Monocytes typically express Ly6G transiently during development while mature granulocytes and peripheral neutrophils retain expression making Ly6G a good cell surface marker for these populations. Ly6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon gamma and is thought to play a role in the development and maturation of lymphocytes. The NIMP-R14 antibody has been shown to be useful for depletion of neutrophils in mice.