About InVivoMAb anti-mouse 4-1BB (CD137)
The 17B5 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF-κB, c-Jun and p38 downstream pathways. The importance of the 4-1BB pathway has been underscored in several diseases, including cancer. The 17B5 antibody has been shown to block 4-1BB-mediated T cell proliferation in vitro.
InVivoMAb anti-mouse 4-1BB (CD137) Specifications
| Isotype | Syrian Hamster IgG |
| Recommended Isotype Control(s) | InVivoMAb polyclonal Syrian hamster IgG(BE0087) |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer(IP0070) |
| Immunogen | Not available or unknown |
| Reported Applications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2 µm filtration |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein A |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| RRID | AB_2687819 |
| Molecular Weight | 150 kDa |
