About InVivoMAb anti-mouse/human Integrin β7

The FIB504 monoclonal antibody reacts with human and mouse Integrin beta 7 which is a 130 kDa glycoprotein belonging to the Ig superfamily. Integrin β7 associates with integrin α4 (CD49d) to form integrin α4β7 also known as LPAM-1 as well as integrin αE (CD103) to form integrin αEβ7. Integrin α4β7 signals when bound to its ligands VCAM-1 (CD106), MAdCAM-1 and fibronectin, while integrin αEβ7 binds to E-cadherin (CD324). Integrin α4β7 is expressed by peripheral lymphocytes, small subsets of thymocytes, and bone marrow progenitors while integrin αEβ7 is expressed on intestinal intraepithelial lymphocytes, T regulatory cells, and a subset of CD8+ T cells in the lamina propria and lymph nodes. Integrin β7 plays roles in the adhesion of immune cells to endothelial cells thereby mediating cell migration and homing during an inflammatory response. The FIB504 antibody has been shown to have blocking activity.