About InVivoPlus anti-mouse OX40 (CD134)
The OX-86 monoclonal antibody reacts with mouse OX-40 also known as CD134. OX-40 is a 50 kDa type I membrane glycoprotein and a member of the TNF receptor superfamily. OX-40 is expressed on activated CD4 and CD8 T cells, but is not found on resting naïve T cells or most resting memory T cells. Although it was originally thought that OX-40 expression was restricted to activated conventional T cells, it has now been visualized on activated regulatory T cells, NKT cells, NK cells, and neutrophils. OX-40 plays a major role in regulating both CD4 and CD8 T cell clonal expansion. It provides a costimulatory signal to an antigen-reacting naive T cells to prolong proliferation, as well as augment the production of several cytokines. This is demonstrated by OX-40 knockout mice which generate fewer primary effector CD4 T cells after immunization. Furthermore, in vivo treatment with an agonist antibody to OX-40 has been shown to strongly enhance the generation of antigen-specific effector T cells and prevent the induction of T cell tolerance. The OX-86 antibody is an agonistic antibody that has been shown to delay tumor growth in vivo.
InVivoPlus anti-mouse OX40 (CD134) Specifications
Isotype | Rat IgG1, κ |
Recommended Isotype Control(s) | InVivoPlus rat IgG1 isotype control, anti-horseradish peroxidase(BP0088) |
Recommended InVivoPure Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer(IP0070) |
Immunogen | Recombinant mouse OX40-CD4 chimeric protein |
Reported Applications |
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Endotoxin |
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Binding Validation | Determined by immunoblot |
Purity |
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Aggregation |
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Formulation |
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Sterility | 0.2 µm filtration |
Production | Purified from tissue culture supernatant in an animal free facility |
Purification | Protein G |
Molecular Weight | 150 kDa |
Murine Pathogen Test Results |
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RRID | AB_1107592 |
Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |