>
产品中心 >
Functional_antibody >
BioXcell/InVivoMAb anti-mouse IL-10/DISCOUNTED ACADEMIC OR NON PROFIT: 50MG/BE0049-A050mg
AboutInVivoMAbanti-mouseIL-10
TheJES5-2A5monoclonalantibodyreactswithmouseIL-10.IL-10isa17-21kDacytokinewhichisprimarilyproducedbymonocytesand,toalesserextent,Th2cells,mastcells,Tregulatorycells,andcertainsubsetsofactivatedTandBcells.IL-10haspleiotropiceffectsinimmunoregulationandinflammation.Itdown-regulatestheexpressionofTh1cytokines,MHCclassIIantigens,andcostimulatorymoleculesonmacrophages.ItalsoenhancesBcellsurvival,proliferation,andantibodyproduction.ThiscytokinecanblockNF-κBactivity,andisinvolvedintheregulationoftheJAK-STATsignalingpathway.Knockoutstudiesinmicesuggestthatthiscytokineisanessentialimmunoregulatorintheintestinaltract.TheJES5-2A5antibodyhasbeenshowntoneutralizethebioactivityofnaturalorrecombinantIL-10.
InVivoMAbanti-mouseIL-10Specifications
| Isotype | RatIgG1, κ |
| RecommendedIsotypeControl(s) | InVivoMAbratIgG1isotypecontrol,anti-horserADIshperoxidase(BE0088) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | RecombinantmouseIL-10 |
| ReportedApplications |
|
| Endotoxin |
|
| Purity |
|
| Formulation |
|
| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredatthestockconcentrationat4°C.Donotfreeze. |
| RRID | AB_1107696 |
| MolecularWeight | 150kDa |
