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BioXcell/InVivoMAb anti-mouse IL-23 (p19)/AMOUNT GREATER THAN 100 MG: (QUOTE ONLY)/BE0313-CUST
About InVivoMAb anti-mouse IL-23 (p19)
The G23-8 monoclonal antibody reacts with the p19 subunit of mouse IL-23. IL-23 is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages. IL-23 has been shown to enhance IFNγ production by memory T cells. Additionally, mouse IL-23 induces the proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Mouse IL-23 (but not IL-12) can also activate mouse memory T cells to produce the potent proinflammatory cytokine IL-17. IL-23 has been shown to be upregulated in certain autoimmune diseases and promote immunity in response to some viral and mycobacterial infections. The G23-8 antibody can specifically neutralize IL-23 bioactivity with no effect on IL-12 p70 bioactivity.
InVivoMAb anti-mouse IL-23 (p19) Specifications
Isotype | Rat IgG1, κ |
Recommended Isotype Control(s) | InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase(BE0088) |
Recommended InVivoPure Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer(IP0070) |
Immunogen | Insect cell-expressed, recombinant mouse IL-23 heterodimer |
Reported Applications |
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Formulation |
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Endotoxin |
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Purity |
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Sterility | 0.2 μM filtered |
Production | Purified from tissue culture supernatant in an animal free facility |
Purification | Protein G |
RRID | AB_2754551 |
Molecular Weight | 150 kDa |
Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |