About InVivoPlus anti-mouse 4-1BB (CD137)
The LOB12.3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF- κB, c-Jun and p38 downstream pathways. The importance of the 4-1BB pathway has been underscored in a number of diseases, including cancer. Agonistic anti-4-1BB antibodies have been reported to induce T cell mediated antitumor immunity. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growth in vivo when administered in combination with immune checkpoint inhibitors.
InVivoPlus anti-mouse 4-1BB (CD137) Specifications
| Isotype | Rat IgG1, κ |
| Recommended Isotype Control(s) | InVivoPlus rat IgG1 isotype control, anti-horseradish peroxidase(BP0088) |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 8.0 Dilution Buffer(IP0080) |
| Immunogen | Mouse CD137 human Fc fusion protein |
| Reported Applications | in vivo activation of 4-1BB |
| Endotoxin |
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| Purity |
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| Aggregation |
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| Formulation |
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| Sterility | 0.2 μM filtered |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein G |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| Murine Pathogen Test Results |
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| RRID | AB_10949016 |
| Molecular Weight | 150 kDa |
