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BioXcell/InVivoMAb anti-mouse VISTA/DISCOUNTED ACADEMIC OR NON PROFIT 5MG/BE0310-A005mg
AboutInVivoMAbanti-mouseVISTA
The13F3monoclonalantibodyreactswithmouseV-domainIgsuppressorofTcellactivation(VISTA)alsoknownasPD-1HandB7-H5.VISTAisa309aatypeItransmembraneglycoproteinandamemberoftheIgsuperfamily.VISTAisexpressedonnaïveandactivatedTcells,NKcells,macrophages,dendriticcells,andneutrophils.VISTAfunctionsasanegativeimmune-checkpointproteinthatsuppressesTcellcytokineproductionandproliferation.VISTAisoverexpressedbytumor-infiltratinglymphocytes,suchasmyeloidcellsandregulatoryTcells.BlockadeofVISTAwiththe13F3antibodyresultsindelayedtumorgrowthinmousemodelsofmelanoma.
InVivoMAbanti-mouseVISTASpecifications
| Isotype | ArmenianHamsterIgG |
| RecommendedIsotypeControl(s) | InVivoMAbpolyclonalArmenianhamsterIgG(BE0091) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | EL4cellsoverexpressingmouseVISTA-RFPandthenboostedwithVISTA-Igfusionprotein |
| ReportedApplications |
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| Formulation |
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| Endotoxin |
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| Purity |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinA |
| RRID | AB_2736990 |
| MolecularWeight | 150kDa |
| Storage | Theantibodysolutionshouldbestoredatthestockconcentrationat4°C.Donotfreeze. |
