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BioXcell/InVivoMAb anti-mouse CD47 (IAP)/REGULAR: 50MG/BE0270-R050mg
AboutInVivoMAbanti-mouseCD47(IAP)
TheMIAP301monoclonalantibodyreactswithmouseCD47otherwiseknownasintegrin-associatedprotein(IAP).CD47isanapproximately50kDaglycosylatedfivetransmembraneproteinthatisubiquitouslyexpressedbybothhematopoieticcellssuchasTandBlymphocytes,monocytes,plateletsanderythrocytesandnon-hematopoieticcells.CD47isinvolvedinarangeofcellularprocesses,includingapoptosis,proliferation,adhesion,andmigration.FurThermore,itplaysakeyroleinimmuneandangiogenicresponses.CD47isareceptorforthrombospondin-1(TSP-1),asecretedglycoproteinthatplaysaroleinvasculardevelopmentandangiogenesis.CD47Ishasbeenfoundtobeoverexpressedinmanydifferenttumorcells.Becauseofthis,anti-CD47monoclonalantibodieshavebeenproposedandstudiedasatherapeutictreatmentforhumancancers.TheMIAP301antibodyhasbeenshowntoneutralizeCD47invivoandinvitro.
InVivoMAbanti-mouseCD47(IAP)Specifications
| Isotype | RatIgG2a, κ |
| RecommendedIsotypeControl(s) | InVivoMAbratIgG2aisotypecontrol,anti-trinitrophenol(BE0089) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredatthestockconcentrationat4°C.Donotfreeze. |
| RRID | AB_2687793 |
| MolecularWeight | 150kDa |
