About InVivoMAb anti-mouse/human VLA-4 (CD49d)
The PS/2 monoclonal antibody reacts with human and mouse VLA-4 α chain also known as CD49d and integrin alpha 4. VLA-4 is a 150 kDa glycoprotein belonging to the integrin family that is expressed by many cell types including T and B lymphocytes, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, and dendritic cells. Integrin α4 associates with integrin β7 to form integrin α4β7 also known as LPAM-1 as well as integrin β1 (CD29) to form integrin α4β1 also known as VLA-4. Integrin α4 plays roles in adhesion and T cell co-stimulation. Integrin α4 ligands include VCAM-1, MAdCAM-1, and fibronectin. The PS/2 antibody is useful for in vivo and in vitro VLA-4 neutralization.
InVivoMAb anti-mouse/human VLA-4 (CD49d) Specifications
| Isotype | Rat IgG2b, κ |
| Recommended Isotype Control(s) | InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin(BE0090) |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 6.5 Dilution Buffer(IP0065) |
| Immunogen | Mouse P815 mast cells |
| Reported Applications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2 μM filtered |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein G |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| RRID | AB_1107657 |
| Molecular Weight | 150 kDa |
