>
产品中心 >
Isotype_control_antibody >
BioXcell/InVivoMAb human IgG1 isotype control/REGULAR 1MG/BE0297-R001mg
About InVivoMAb anti-mouse CD122 (IL-2Rβ)
The TM-beta 1 monoclonal antibody reacts with mouse CD122 also known as the IL-2 receptor beta chain. CD122 is a 70-75 kDa subunit of the IL-2 receptor and the IL-15 receptor. CD122 is expressed on NK cells and at lower levels by T lymphocytes, B lymphocytes, monocytes, and macrophages. The IL-2R has been shown to play roles in lymphocyte differentiation, activation, and proliferation. In complex with IL-2Rα, IL-2R binds IL-2 with relatively low affinity however, when CD122 combines with IL-2Rα and the common gamma chain (CD132) the complex binds IL-2 with high affinity. The TM-beta 1 antibody is reported to inhibit binding of IL-2 to the IL-2R. Additionally, this antibody has been shown to deplete CD122 expressing NK cells with administered in vivo.
InVivoMAb anti-mouse CD122 (IL-2Rβ) Specifications
| Isotype | Rat IgG2b, κ |
| Recommended Isotype Control(s) | InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin(BE0090) |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 8.0 Dilution Buffer(IP0080) |
| Immunogen | Mouse IL-2Rβ transfected cell line (TART-mβ cells) |
| Reported Applications |
|
| Endotoxin |
|
| Purity |
|
| Formulation |
|
| Sterility | 0.2 µm filtration |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein G |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| RRID | AB_2687820 |
| Molecular Weight | 150 kDa |
