About InVivoMAb anti-human Ganglioside GD2
The 14G2a monoclonal antibody reacts with human ganglioside GD2 a sialic-acid bearing glycolipid that is involved in mediating cell attachment to the extracellular matrix. Ganglioside GD2 is expressed on tumors of neuroectodermal origin including human neuroblastoma and melanoma. The tumor specific expression of GD2 makes it a suitable target for immunotherapy with monoclonal antibodies or with artificial T cell receptors. Clone 14G2a is an isotype switch variant selected from the parental IgG3-producing hybridoma 14.18 and has identical reactivity as the parental antibody.
InVivoMAb anti-human Ganglioside GD2 Specifications
| Isotype | Mouse IgG2a, κ |
| Recommended Isotype Control(s) | InVivoMAb mouse IgG2a isotype control, unknown specificity(BE0085) |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer(IP0070) |
| Immunogen | Neuroblastoma cell line LAN-1 |
| Reported Applications |
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| Formulation |
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| Endotoxin |
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| Purity |
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| Sterility | 0.2 μM filtered |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein A |
| Molecular Weight | 150 kDa |
| RRID | AB_2819045 |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
