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当前位置: 首页 > 产品中心 > Functional_antibody > BioXcell/InVivoMAb抗小鼠FasL(CD178)/普通5MG/BE0319-R005mg
商品详细BioXcell/InVivoMAb抗小鼠FasL(CD178)/普通5MG/BE0319-R005mg
BioXcell/InVivoMAb抗小鼠FasL(CD178)/普通5MG/BE0319-R005mg
BioXcell/InVivoMAb抗小鼠FasL(CD178)/普通5MG/BE0319-R005mg
商品编号: BE0319-R005mg
品牌: BioXcell inc
市场价: ¥10500.00
美元价: 6300.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

About InVivoMAb anti-mouse FasL (CD178)

The MFL3 monoclonal antibody reacts with mouse Fas Ligand (FasL) also known as CD178, CD95 Ligand, and TNFSF6. FasL is a 40 kDa type II transmembrane glycoprotein and a member of the TNF superfamily. FasL is expressed on activated T cells and in spleen, testis, and eye. Upon binding to its receptor CD95 (Fas) FasL induces apoptotic cell death to maintain peripheral tolerance. Some tumors over-express FasL and induce the apoptosis of infiltrating lymphocytes, allowing the tumor to escape the effects of an immune response. CD178/CD95 interactions are also thought to play a role in the proliferation of CD8+ cells and neutrophil extravasation, chemotaxis and survival. The MFL3 antibody has been reported to block CD178/CD95 induced apoptosis.

InVivoMAb anti-mouse FasL (CD178) Specifications

Isotype

Armenian Hamster IgG

Recommended Isotype Control(s)InVivoMAbpolyclonal Armenian hamster IgG(BE0091)
Recommended InVivoPure Dilution BufferInVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

BHK cells expressing B6 mouse FasL

Reported Applications
  • in vivo FasL blockade
  • In vitro FasL blockade
  • Functional assay
  • Immunohistochemistry (paraffin)
  • Flow Cytometry
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein A

Molecular Weight

150 kDa

RRID

AB_2819046

Storage

The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

品牌介绍
Bio X Cell采用最先进的发酵技术;包括搅拌罐发酵罐和波包系统;我们的生产能力从5升到500升不等。Bio X Cell提供从现有杂交瘤细胞系产生的抗体的生产和纯化服务。这些杂交瘤通常在客户的实验室中开发或在公共领域可用。该服务包括在细胞培养物中发酵杂交瘤,通过离心收获细胞培养上清液以及通过30 kDa超滤浓缩。通过蛋白A或G亲和色谱进行纯化。将纯化的抗体透析到PBS中并过滤除菌。我们所有定制产品的内毒素水平<2EU / mg。我们还提供冻结细胞系,现场细胞系存储和MAP测试的额外费用。