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当前位置: 首页 > 产品中心 > Isotype_control_antibody > BioXcell/InVivoPlus human IgG1 isotype control/DISCOUNTED ACADEMIC OR NON PROFIT 50MG/BP0297-A050mg
商品详细BioXcell/InVivoPlus human IgG1 isotype control/DISCOUNTED ACADEMIC OR NON PROFIT 50MG/BP0297-A050mg
BioXcell/InVivoPlus human IgG1 isotype control/DISCOUNTED ACADEMIC OR NON PROFIT 50MG/BP0297-A050mg
BioXcell/InVivoPlus human IgG1 isotype control/DISCOUNTED ACADEMIC OR NON PROFIT 50MG/BP0297-A050mg
商品编号: BP0297-A050mg
品牌: BioXcell inc
市场价: ¥78000.00
美元价: 46800.00
产地: 美国(厂家直采)
公司:
产品分类: 同型对照抗体
公司分类: Isotype_control_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

About InVivoMAb anti-mouse CTLA-4 (CD152)

The 9H10 monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. CTLA-4 is a 33 kDa cell surface receptor encoded by the Ctla4 gene that belongs to the CD28 family of the Ig superfamily. CTLA-4 is expressed on activated T and B lymphocytes. CTLA-4 is structurally similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to the B7 family members B7-1 (CD80) and B7-2 (CD86). Upon ligand binding, CTLA-4 negatively regulates cell-mediated immune responses. CTLA-4 plays roles in induction and/or maintenance of immunological tolerance, thymocyte development, and regulation of protective immunity. The critical role of CTLA-4 in immune down-regulation has been demonstrated in CTLA-4 deficient mice, which succumb at 3-5 weeks of age due to the development of a lymphoproliferative disease. CTLA-4 is among a group of inhibitory receptors being explored as cancer treatment targets through immune checkpoint blockade. The 9H10 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding.

InVivoMAb anti-mouse CTLA-4 (CD152) Specifications

Isotype

Syrian Hamster IgG

Recommended Isotype Control(s)InVivoMAb polyclonal Syrian hamster IgG(BE0087)
Recommended InVivoPure Dilution BufferInVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

Mouse CTLA-4-human IgG1 fusion protein

Reported Applications
  • in vivo CTLA-4 neutralization
  • in vitro CTLA-4 neutralization
  • Western blot
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

RRID

AB_10950184

Molecular Weight

150 kDa

品牌介绍
Bio X Cell采用最先进的发酵技术;包括搅拌罐发酵罐和波包系统;我们的生产能力从5升到500升不等。Bio X Cell提供从现有杂交瘤细胞系产生的抗体的生产和纯化服务。这些杂交瘤通常在客户的实验室中开发或在公共领域可用。该服务包括在细胞培养物中发酵杂交瘤,通过离心收获细胞培养上清液以及通过30 kDa超滤浓缩。通过蛋白A或G亲和色谱进行纯化。将纯化的抗体透析到PBS中并过滤除菌。我们所有定制产品的内毒素水平<2EU / mg。我们还提供冻结细胞系,现场细胞系存储和MAP测试的额外费用。