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BioXcell/InVivoMAb抗小鼠CD132（普通γ链）/含量大于100 MG：（仅报价）/BE0271-CUST
About InVivoMAb anti-mouse CD132 (common γ chain)
The 3E12 monoclonal antibody reacts with mouse CD132 also known as the common gamma chain and IL-2 receptor gamma chain. CD132 is a 64-70 kDa type I transmembrane glycoprotein belonging to the Ig superfamily. It is expressed by a wide range of cells including T and B lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential subunit of the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21 receptors. Ligand binding induces tyrosine phosphorylation and initiates signaling through the JAK/STAT pathway. The 3E12 antibody has been reported to block the bioactivity of IL-4, IL-9, and IL-15 and inhibit the ligand/receptor binding of IL-4 and IL-7.
InVivoMAb anti-mouse CD132 (common γ chain) Specifications
| Isotype | Rat IgG2b |
| Recommended Isotype Control(s) | InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin(BE0090) |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer(IP0070) |
| Immunogen | Rat myeloma YB2/0 transfected with mouse cytoplasmic-tailless CD132 |
| Reported Applications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2 μM filtered |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein G |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| RRID | AB_2687794 |
| Molecular Weight | 150 kDa |
