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当前位置: 首页 > 产品中心 > monoclonal_antibody > BioXcell/InVivoMAb抗小鼠CD54(ICAM-1)/普通:100MG/BE0020-1-R100mg
商品详细BioXcell/InVivoMAb抗小鼠CD54(ICAM-1)/普通:100MG/BE0020-1-R100mg
BioXcell/InVivoMAb抗小鼠CD54(ICAM-1)/普通:100MG/BE0020-1-R100mg
BioXcell/InVivoMAb抗小鼠CD54(ICAM-1)/普通:100MG/BE0020-1-R100mg
商品编号: BE0020-1-R100mg
品牌: BioXcell inc
市场价: ¥65000.00
美元价: 39000.00
产地: 美国(厂家直采)
公司:
产品分类: 单克隆抗体
公司分类: monoclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

About InVivoMAb anti-mouse CD54 (ICAM-1)

The YN1/1.7.4 monoclonal antibody reacts with mouse CD54 also known as Intercellular Adhesion Molecule-1 (ICAM-1). CD54 is a 90 kDa single-chain transmembrane glycoprotein and a member of the Ig superfamily. CD54 is typically expressed on non-hematopoietic cells such as endothelial cells, thymic epithelial cells, and fibroblasts but can also be expressed on macrophages, T-lymphoblasts, germinal center B cells and dendritic cells. CD54 is a ligand for LFA-1, a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells via CD54/LFA-1 to facilitate transmigration into tissues. Pro-inflammatory cytokines such as IL-1, TNF and IFNγ induce CD54 expression on endothelial cells and fibroblasts. The YN1/1.7.4 antibody has been shown to neutralize CD54 in vivo and inhibit CXCL1, IFNγ, and IL-17 production and neutrophil infiltration into inflammatory lesions.

InVivoMAb anti-mouse CD54 (ICAM-1) Specifications

Isotype

Rat IgG2b, κ

Recommended Isotype Control(s)InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin(BE0090)
Recommended InVivoPure Dilution BufferInVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

NS-1 mouse myeloma cells

Reported Applications
  • in vivo ICAM-1 neutralization
  • Immunohistochemistry (frozen)
  • ELISA
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

RRID

AB_1107661

Molecular Weight

150 kDa

品牌介绍
Bio X Cell采用最先进的发酵技术;包括搅拌罐发酵罐和波包系统;我们的生产能力从5升到500升不等。Bio X Cell提供从现有杂交瘤细胞系产生的抗体的生产和纯化服务。这些杂交瘤通常在客户的实验室中开发或在公共领域可用。该服务包括在细胞培养物中发酵杂交瘤,通过离心收获细胞培养上清液以及通过30 kDa超滤浓缩。通过蛋白A或G亲和色谱进行纯化。将纯化的抗体透析到PBS中并过滤除菌。我们所有定制产品的内毒素水平<2EU / mg。我们还提供冻结细胞系,现场细胞系存储和MAP测试的额外费用。