4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:抗体类,InVivo Mab抗体,InVivo Plus抗体,InVivo纯稀释缓冲液,ReadyTag抗体,融合蛋白
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > monoclonal_antibody > BioXcell/InVivoPlus rat IgG1 isotype control, anti-horseradish peroxidase/REGULAR: 25MG/BP0088-R025mg
商品详细BioXcell/InVivoPlus rat IgG1 isotype control, anti-horseradish peroxidase/REGULAR: 25MG/BP0088-R025mg
BioXcell/InVivoPlus rat IgG1 isotype control, anti-horseradish peroxidase/REGULAR: 25MG/BP0088-R025mg
BioXcell/InVivoPlus rat IgG1 isotype control, anti-horseradish peroxidase/REGULAR: 25MG/BP0088-R025mg
商品编号: BP0088-R025mg
品牌: BioXcell inc
市场价: ¥44000.00
美元价: 26400.00
产地: 美国(厂家直采)
公司:
产品分类: 单克隆抗体
公司分类: monoclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

About InVivoMAb anti-mouse 4-1BB (CD137)

The 3H3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF-κB, c-Jun and p38 downstream pathways. The importance of the 4-1BB pathway has been underscored in a number of diseases, including cancer. Agonistic anti-4-1BB antibodies have been reported to induce T cell mediated antitumor immunity. The 3H3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling in vivo.

InVivoMAb anti-mouse 4-1BB (CD137) Specifications

Isotype

Rat IgG2a

Recommended Isotype Control(s)InVivoMAb rat IgG2a isotype control, anti-trinitrophenol(BE0089)
Recommended InVivoPure Dilution BufferInVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

Mouse CD137 human Fc fusion protein

Reported Applications
  • in vivo 4-1BB stimulation
  • in vitro 4-1BB stimulation
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

RRID

AB_2687721

Molecular Weight

150 kDa

品牌介绍
Bio X Cell采用最先进的发酵技术;包括搅拌罐发酵罐和波包系统;我们的生产能力从5升到500升不等。Bio X Cell提供从现有杂交瘤细胞系产生的抗体的生产和纯化服务。这些杂交瘤通常在客户的实验室中开发或在公共领域可用。该服务包括在细胞培养物中发酵杂交瘤,通过离心收获细胞培养上清液以及通过30 kDa超滤浓缩。通过蛋白A或G亲和色谱进行纯化。将纯化的抗体透析到PBS中并过滤除菌。我们所有定制产品的内毒素水平<2EU / mg。我们还提供冻结细胞系,现场细胞系存储和MAP测试的额外费用。