AboutInVivoMAbanti-mouse4-1BB(CD137)
The3H3monoclonalantibodyreactswithmouse4-1BB,aTNFreceptorsuperfamilymemberalsoknownasCD137.4-1BBisa39kDatransmembraneproteinexpressedbyTlymphocytes,NKcells,dendriticcells,granulocytes,andmastcells.Uponbindingitsligand4-1BBL,4-1BBprovidescostimulatorysignalstobothCD4andCD8TcellsthroughtheactivationofNF-κB,c-Junandp38downstreampathways.Theimportanceofthe4-1BBpathwayhasbeenunderscoredinanumberofdiseases,includingcancer.AgoNISTicanti-4-1BBantibodieshavebeenreportedtoinduceTcellmediatedantitumorimmunity.The3H3antibodyisanagonisticantibodythathasbeenshowntostimulate4-1BBsignalinginvivo.
InVivoMAbanti-mouse4-1BB(CD137)Specifications
| Isotype | RatIgG2a |
| RecommendedIsotypeControl(s) | InVivoMAbratIgG2aisotypecontrol,anti-trinitrophenol(BE0089) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | MouseCD137humanFcfusionprotein |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredatthestockconcentrationat4°C.Donotfreeze. |
| RRID | AB_2687721 |
| MolecularWeight | 150kDa |
