About InVivoMAb anti-mouse Podoplanin (gp38)

The 8.1.1 monoclonal antibody reacts with mouse podoplanin (PDPN) also known as glycoprotein 38 (gp38). Podoplanin is a 36 to 43 kDa mucin-type glycoprotein expressed by kidney glomerular epithelial cells (podocytes), lymphatic endothelial cells, and fibroblastic reticular cells. Podoplanin is the endogenous ligand for the C-type lectin receptor CLEC-2, which is expressed by platelets and DCs. CLEC-2 signaling is critical for platelet activation, the migration of activated DCs to draining lymph nodes, and maintenance of vascular integrity and lymph node structure. Podoplanin is critical for fibroblastic reticular cell contractility as well as during fetal development for blood-lymph separation and lung organogenesis. Podoplanin overexpression in cancer correlates with increased invasion and metastasis. The 8.1.1 antibody has been shown to block podoplanin in vivo and in vitro.