InVivoMAb anti-mouse CD69

The CD69.2.2 monoclonal antibody reacts with mouse CD69, an 85 kDa type II C-type lectin. CD69 expression is rapidly induced upon cell activation in all leukocytes. CD69 is thought to be a negative regulator of the immune response in part through modulating the production of TGF-β. Studies in CD69-deficient mice have revealed that CD69 plays crucial roles in the pathogenesis of various inflammatory diseases including arthritis, asthma, and colitis. When administered in vivo the CD69.2.2 antibody causes CD69 to be internalized but does not deplete CD69⁺ cells. Anti-CD69-treated mice resemble CD69^-/- mice to a remarkable degree. The CD69.2.2 antibody has been shown to activate NK cells in vivo and in vitroand promote anti-tumor responses.

This Antibody Is Useful For:

• in vivo down-regulation of CD69 expression
• Functional assays

As always Bio X Cell antibodies are specifically formulated for in vivo use and feature:

• 95% purity
• Ultra-low endotoxin levels
• Preservative, stabilizer, and carrier protein-free

Don’t forget to add the recommended isotype control antibody and dilution buffer.